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30ML‎ ‎ ‎ BESPOKE

THE MENOPAUSE CREAM

Plumpness‎ ‎ ‎ Firmness‎ ‎ ‎ Radiance

OestraRX is a prescription-strength, oestrogen-based skincare formulation designed to counteract the often-overlooked impact of hormonal ageing on the skin. With up to 30% of dermal collagen lost within the first five years of menopause, skin can become thinner, drier, and less resilient. This targeted treatment restores elasticity, refines pores and combats dryness and dullness.

Specifically developed for women aged 40 and over, including those in perimenopause and postmenopause, OestraRX provides essential support for skin experiencing hormonal shifts. By addressing the unique needs of evolving skin, it delivers much-needed focus on this critical yet underrepresented aspect of ageing.

£60/month (£120 for a 30ml 2 month supply)

Formulations

THE MENOPAUSE CREAM

Oestriol 0.3%
Vitamin A 1%
Vitamin E 1%
Vitamin C 1%
Hyaluronic acid 1%

The active ingredient in OestraRX is topical oestriol, a bioidentical form of oestrogen. This ingredient helps replenish declining oestrogen levels in the skin during perimenopause and menopause, stimulating collagen production, improving elasticity, and increasing hydration. The result is a clinically proven approach to counteract the effects of ageing.

Prescription is not guaranteed and is subject to dermatological assessment.

KEY BENEFITS

Enhances skin plumpness and reduces signs of ageing
Restores elasticity while minimising wrinkles
Reduces pore size for a refined complexion
Hydrates and revitalises dull, dry skin
Dermatologist-designed with potent prescription-strength ingredients

How does OestraRX work?

OestraRX contains oestriol which is one of the three naturally occurring forms of oestrogen in the body, becoming more prominent during menopause. Unlike oestradiol, the most potent form of oestrogen, oestriol is a milder variant due to its shorter binding duration to oestrogen receptors. This characteristic makes it particularly suitable for topical applications. Oestriol has been utilised in vaginal creams for hormone replacement therapy for several decades, underscoring its established efficacy in addressing menopausal symptoms.

During the initial five years of menopause, women can experience up to a 30% loss in dermal collagen, leading to skin thinning and reduced elasticity. This is driven by the decline in oestrogen levels, which play a crucial role in maintaining skin hydration, barrier function, and collagen synthesis. Beyond skin health, declining oestrogen is also associated with bone density loss, increased cardiovascular risk, and increased risk of metabolic conditions.

Research indicates that topical oestriol can enhance skin vitality by stimulating collagen production and improving hydration. In addition to oestriol, OestraRX is formulated with hyaluronic acid, vitamin C, and vitamin A, creating a powerful combination for skin rejuvenation. Hyaluronic acid delivers deep hydration, helping to plump and smooth the skin while reducing the appearance of fine lines. Vitamin C is a potent antioxidant that brightens the complexion, supports collagen synthesis, and protects against environmental damage. Vitamin A promotes skin renewal. Together, these clinically backed ingredients work in synergy to restore skin health, enhance radiance, and support the skin’s natural repair processes.

How to Use

After cleansing, dispense one pump onto the affected areas of your face and gently massage it in.
It can be applied in the morning (AM) or evening (PM), depending on your preference.
OestraRX can be used alongside tretinoin formulations.
With consistent use, visible improvements are typically seen within 12 weeks.
Each bottle provides approximately a two-month supply (30ml).

PAIRS WELL WITH

Anti-ageing tretinoin formulations

How much does it cost?

Most of our skincare formulations are on subscription at £120 per 30ml (2 months supply). Your 30ml bottle is delivered every 8 weeks.

You can change this to 12 weeks in your dashboard.

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menopause faqs

Have a question about how it works? Check out our other FAQs or drop us a message.

Yes! The OestraRX is a hydrating cream, specifically formulated for dry and sensitive skin.

The formula contains Oestriol, Vitamin C, Vitamin A, Vitamin E and Hyaluronic Acid for maximum skin rejuvenation.

Full ingredient list: Oestriol 0.3%, Hyaluronic acid 1%, Vitamin A 1% Vitamin C 1%, Vitamin E 1%, Aloe Barbadensis Leaf Juice, C12-14 Isoparaffin, Caprylic/Capric Triglyceride, Deionised Water, Laureth-7, Phenoxyethanol, Polyacrylamide, and Triethylene Glycol.

OestraRX is designed for women experiencing the skin changes that come with hormonal shifts during perimenopause and postmenopause. As oestrogen levels decline, skin can become drier, thinner, and less firm. This treatment is ideal for those looking to support their skin’s vitality, restore elasticity, and address visible signs of ageing with a targeted, hormone-based approach.

Yes, OestraRX can used alongside prescription tretinoin formulations and can be applied in either the AM or PM. If applying in the evening, allow tretinoin to absorb before layering OestraRX on top.

Clinical research has demonstrated that topical oestriol, when applied as a face cream, does not lead to systemic absorption. In a six-month study on postmenopausal women, blood tests showed no increase in circulating oestrogen levels, reinforcing that the treatment remains localised to the skin. This suggests that topical oestriol can provide targeted skin benefits without systemic hormonal effects, making it a well-tolerated option for those seeking to support skin health during hormonal changes. As with any prescription treatment, we take a personalised approach to assess suitability and consider your medical history and individual needs to ensure this is the right choice for you.

The relationship between hormonal treatments and melasma has been primarily documented with systemic therapies, such as oral contraceptives. Studies have shown that a significant percentage of women taking oral contraceptives develop melasma, highlighting a clear association between systemic hormone exposure and this skin condition. Regarding topical oestriol, evidence is more limited. However, there have been case reports where the use of a topical estrogen cream was associated with the development of melasma.

If you are prone to hyperpigmentation, it is important to introduce OestraRX gradually and monitor your skin's response. If you notice any worsening of pigmentation, discontinue use and consult your prescriber. Additionally, consistent use of a high-SPF, broad-spectrum sunscreen is essential, as UV exposure is a key trigger for melasma.

Yes, OestraRX can be used alongside systemic hormone replacement therapy (HRT), but this should be assessed on an individual basis. While systemic HRT works internally to restore oestrogen levels throughout the body, OestraRX is a topical treatment designed to act locally on the skin, helping to restore elasticity, hydration, and collagen levels. During your consultation, our expert team will review your medical history, current treatments, and individual needs to ensure that OestraRX complements your existing HRT regimen safely and effectively.